Methods and reagents for regulating apoptosis
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United States of America Patent
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Issued Date -
Sep 11, 2003
app pub date -
Mar 4, 2002
filing date -
Mar 2, 2001
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Abandoned
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Abstract
The present invention relates to methods and reagents useful for inhibition of apoptosis. Specifically, the invention relates to methods to identify agents that is either pro-apoptotic or anti-apoptotic, especially by affecting the signal transduction pathways of BAK protein and/or M11L protein. The invention also provides business methods, diagnostic kits for identification of pro- or anti-apoptotic agents. Another aspect of the invention provides a method to identify M11L-interacting polypeptides using mass spectrometry.
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