Method of enhancing the effect of collagenase on wounds
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United States of America Patent
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Issued Date -
Sep 11, 2003
app pub date -
Mar 11, 2002
filing date -
Mar 11, 2002
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Abstract
The debridement of wounds, and particularly burn wounds, is more effectively accomplished by starting with a first substance comprising a mixture of collagenase and a non-aqueous excipient and a second substance comprising an aqueous excipient and, preferably, a cream such as an antibiotic cream, both of which substances have a satisfactory shelf life, and treating the wound by combining those two substances and promptly applying the resulting combination to the wound. Shelf life requirements are satisfied, and the effect of applying the resulting combination to the wound promptly after the combination has been formed results in a more effective debridement than would be expected from the application of other collagenase substances.
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