Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins

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United States of America Patent

PATENT NO 7388085
APP PUB NO 20030166165A1
SERIAL NO

10361376

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Abstract

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The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

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Patent Owner(s)

Patent OwnerAddress
ZOETIS SERVICES LLC10 SYLVAN WAY PARSIPPANY NJ 07054

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Yan Santa Clara, CA 884 10448
Gustafsson, Claes Belmont, CA 69 4255
Kim, Seran Waukegan, IL 38 4
Krebber, Anke Palo Alto, CA 28 517
Minshull, Jeremy S Los Altos, CA 28 1527
Raillard, Sun Ai Mountain View, CA 15 507
Stutzman-Engwall, Kim J East Lyme, CT 17 39

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