Methods for predicting functional and structural properties of polypeptides using sequence models
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United States of America Patent
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Issued Date -
Aug 28, 2003
app pub date -
Dec 28, 2001
filing date -
Dec 29, 2000
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Abandoned
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Abstract
The invention provides a method for identifying a polypeptide that binds a ligand. The method includes the steps of (a) comparing a sequence of a polypeptide to a sequence model for polypeptides that bind a ligand, wherein the sequence model comprises representations of amino acids consisting of a subset of amino acids, the subset of amino acids having one or more atom within a selected distance from a bound ligand in the polypeptides that bind the ligand; and (b) determining a relationship between the sequence and the sequence model, wherein a correspondence between the sequence and the sequence model identifies the polypeptide as a polypeptide that binds the ligand.
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