Water-soluble polymer conjugates of retinoic acid
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United States of America Patent
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Issued Date -
Aug 28, 2003
app pub date -
Oct 30, 2002
filing date -
Oct 30, 2001
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Abandoned
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Abstract
The present invention provides water-soluble polymer conjugates of retinoic acid. The conjugates of the invention are prepared by covalent attachment of a water-soluble and non-peptidic polymer such as polyethylene glycol to a retinoid such as retinoic acid. The polymer portion of the conjugate may be linear (i.e., prepared using an end-capped or methoxy PEG or a linear bifunctional PEG), branched or forked. The conjugates of the invention are water soluble, and are, in particular, useful for inhalation therapy of conditions of the respiratory tract responsive to retinoid therapy.
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