Methods for the treatment of primary headache disorders using prostanoid EP4 receptor antagonists, and assays for agents for such treatment
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United States of America Patent
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app pub date -
Feb 19, 2003
filing date -
Sep 25, 1998
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Abstract
The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP.sub.4 receptor for prostaglandin E2. Particular EP.sub.4 receptor antagonists include azole compounds of formula (I): 1 wherein R.sup.1 is a group such as lower alkyl substituted with carboxy; R.sup.2 is hydrogen or lower alkyl, R.sup.3 and R.sup.4 are aryl optionally substituted with halogen, 2 in which --A.sup.1-- is a single bond or lower alkylene, 3 is a cyclo group, --A.sup.3-- is a single bond or lower alkylene, and X is O, NH or S; or a salt or its solvate thereof.
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