Molecular sensors activated by disinhibition
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United States of America Patent
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Issued Date -
Aug 21, 2003
app pub date -
Feb 14, 2002
filing date -
Feb 14, 2002
priority date (Note) -
Abandoned
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Abstract
The current invention provides methods and systems for detecting the presence of a target molecule either in vitro or in vivo. The systems of the invention comprise interacting components, a reporter and a low-affinity inhibitor of the reporter, each of which is fused to a member of a binding pair. A target molecule that interferes with binding of the binding pair members can therefore be identified by detecting activation of the reporter molecule.
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