24-sulfur-substituted analogs of 1alpha, 25-dihydroxy vitamin D3
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United States of America Patent
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Issued Date -
Aug 7, 2003
app pub date -
Aug 22, 2002
filing date -
Aug 22, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention provides novel C24-aryl sulfone analogs of 1.alpha.,25-dihydroxy vitamin D.sub.3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1.alpha.,25-dihydroxy vitamin D.sub.3, for example, cell-proliferative disorders.
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