Method of identifying insulin secretion stimulating compounds, and the use of such compounds in treating insulin-secretion related disorders
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United States of America Patent
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Issued Date -
Aug 7, 2003
app pub date -
Dec 3, 2002
filing date -
Jan 28, 2002
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Abstract
Calcium Induced Calcium Release (CICR) in .beta.-cells has been found to be a novel target for stimulating insulin secretion in a glucose-dependent manner. The present invention relates to a method of identifying compounds that stimulate insulin secretion in a context-dependent manner based on the finding that compounds stimulating insulin secretion in a glucose-dependent manner are able to elicit periodic amplified Ca.sup.2+ release in .beta.-cells. The invention also relates to the use of such compounds, for the manufacture of a medicament for use in the treatment of defective insulin secretion related disorders, especially type 2 diabetes.
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