Conformationally constrained L-nucleosides
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United States of America Patent
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Issued Date -
Jul 31, 2003
app pub date -
Feb 14, 2003
filing date -
May 11, 1999
priority date (Note) -
Abandoned
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Abstract
L-nucleosides are conformationally constrained by at least one additional ring formed by a bridge connecting at least two atoms within a sugar moiety of the nucleoside. While a single additional ring is formed by bridging C.sub.1-C.sub.4 atoms, two additional rings are formed by bridging both C.sub.1-C.sub.2, and C.sub.3-C.sub.4 atoms, or C.sub.1-C.sub.3 and C.sub.2-C.sub.4 atoms by bridges having the general structure A--B--Z. The conformationally constrained nucleosides may be incorporated into oligonucleotides and dinucleotides, and it is contemplated that compositions including the conformationally constrained nucleosides may have superior viral inhibitory or antineoplastic properties.
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