Polymer stabilized neuropeptides
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United States of America Patent
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Issued Date -
Jul 31, 2003
app pub date -
Jan 30, 2003
filing date -
Oct 4, 1999
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Abandoned
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Abstract
A substantially hydrophilic conjugate is provided having a peptide that is capable of passing the blood-brain barrier covalently linked to a water-soluble nonpeptidic polymer such as polyethylene glycol. The conjugate exhibits improved solubility and in vivo stability and is capable of passing the blood-brain barrier of an animal.
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