Polymer conjugates of protein kinase C inhibitors
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United States of America Patent
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Issued Date -
Jul 31, 2003
app pub date -
Oct 29, 2002
filing date -
Oct 29, 2001
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Abandoned
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Abstract
The invention provides polymer conjugates of protein kinase C (PKC) inhibitors comprising a polymer, such as poly(ethylene glycol), covalently attached to a PKC inhibitor, such as a bisindolylmaleimide molecule. The linkage between the polymer and the PKC inhibitor is preferably hydrolytically degradable. The invention also includes a pharmaceutical composition comprising a polymer conjugate of a PKC inhibitor and a method of treating any condition responsive to a PKC inhibitor by administering a polymer conjugate of the invention.
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