N-heterocyclic inhibitors of TNF-alpha expression
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United States of America Patent
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Issued Date -
Jul 24, 2003
app pub date -
Jun 26, 2002
filing date -
Jun 26, 2001
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Abandoned
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Abstract
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): 1 Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-.alpha. expression utilizing compounds of the present invention are also disclosed.
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