Computer-directed assembly of a polynucleotide encoding a target polypeptide
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United States of America Patent
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Issued Date -
Jul 24, 2003
app pub date -
Jan 18, 2002
filing date -
Jan 19, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention outlines a novel approach to utilizing the results of genomic sequence information by computer-directed polynucleotide assembly based upon information available in databases such as the human genome database. Specifically, the present invention may be used to select, synthesize and assemble a novel, synthetic target polynucleotide sequence encoding a target polypeptide. The target polynucleotide may encode a target polypeptide that exhibits enhanced or altered biological activity as compared to a model polypeptide encoded by a natural (wild-type) or model polynucleotide sequence.
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