Method for detecting pathogenic prion proteins by means of mass spectroscopy
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United States of America Patent
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Issued Date -
Jul 17, 2003
app pub date -
Jan 16, 2003
filing date -
Jan 17, 2002
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Abstract
A method for detecting one or more pathogenic prion proteins in a sample, which can be of a body fluid of human or animal origin, and which contains a PrP protein that assumes a natural, nonpathogenic conformation, PrP.sup.C, and a pathogenic conformation, termed PrP.sup.Sc, is described. The method can comprise: providing a sample suspected of containing the pathogenic form of at least one prion protein; exposing the sample to a chemical agent under conditions where the chemical agent and the prion protein or proteins react to form at least one covalent bond involving the prion protein or proteins; and mass-spectroscopically analyzing the resulting prion protein or proteins to detect the presence of the pathogenic form of the prion protein or proteins; wherein at least one additional peak is observed in the mass spectrum when the pathogenic form of a prion protein is present.
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