Self-emulsifying matrix type trandermal preparation

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United States of America Patent

APP PUB NO 20030129219A1
SERIAL NO

10239529

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Abstract

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The present invention relates to a novel pharmaceutical composition of a self-emulsifying matrix preparation, which is a preparation for transmucosal or transdermal absorption in which a self-emulsifying drug delivery system is grafted to a polymeric matrix preparation. For this, fatty alcohol, fatty acid or their derivatives of 6 to 20 carbon atoms having a drug absorption-accelerating action through the skin or mucous membrane is used as an oil phase. Also, to increase the drug content in the matrix, a liquid phase material having a boiling point of 100.degree. C. or more is used as a solution adjuvant. Using such materials, the self-emulsifying system with a surfactant is prepared. A hydrophilic or hydrophobic polymer is added and dissolved in the self-emulsifying system, and the resulting mixture is dried to prepare the matrix preparation containing the self-emulsifying system. The self-emulsifying matrix preparation thus prepared maintains a constant drug-releasing rate during its application period by virtue of its excellent stability and exhibits an extraordinarily high skin-absorption rate.

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Patent Owner(s)

Patent OwnerAddress
CHONG KUN DANG PHARMACEUTICAL CORPSEOUL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hong, Chung Il Chicago, IL 17 259
Ki, Min Hyo Cheonan-city, Choongchug-namdo, KR 14 126
Kweon, Don Sun Seoul, KR 1 20
Lee, Seok Kyu Choongchug-namdo, KR 25 179
Shin, Hee Jong Pucheon-city, KR 29 244

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