Homocysteinylated transthyretin

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United States of America Patent

APP PUB NO 20030124616A1
SERIAL NO

10177807

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention is generally directed to the discovery of homocysteinylated proteins and its importance as an indicator of diseased states. In preferred embodiments of the present invention the isolation, detection, and use of homocysteinylated transthyretin are also provided. More preferably, detection and isolation of a homocysteinylated transthyretin complex from a biological fluid is provided in the present invention, as well as methods and compositions utilizing homocysteinylated transthyretin in the detection of homocysteine or elevated levels of homocysteine. More particularly, the present invention is directed to homocysteinylated transthyretin and its use as a marker for the diagnosis of homocysteinemia, hyperhomocysteinemia, and diseases associated therewith.

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Patent Owner(s)

Patent OwnerAddress
TRUSTEES OF BOSTON UNIVERSITY THEONE SHERBORN STREET BOSTON MA 02215

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Costello, Catherine Reading, MA 2 12
Jacobsen, Donald W Cleveland, OH 1 9

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