Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
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United States of America Patent
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Issued Date -
Jul 3, 2003
app pub date -
Jan 2, 2003
filing date -
Jan 2, 2002
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Abstract
Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents.
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