Hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity
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United States of America Patent
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Issued Date -
Jun 19, 2003
app pub date -
Jul 9, 2002
filing date -
Jul 9, 2001
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Abstract
The present invention concerns the generation of hydroxamic acid thrombospondin-peptide analogs that inhibit aggrecanase activity. These analogs are useful in the treatment of diseases characterized by cartilage degradation, such as osteoarthritis, rheumatoid arthritis spondylarthropathies, and septic arthritis. The invention describes a novel small molecule, enzyme inhibitor that binds both the enzyme and its naturally occurring substrate.
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