Method for generating, screening and dereplicating natural product libraries for the discovery of therapeutic agents
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United States of America Patent
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Issued Date -
Jun 19, 2003
app pub date -
Jun 27, 2002
filing date -
Jun 27, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention relates generally to a technology platform, referred to as Phytologix.TM. for the discovery of novel bioactive pharmaceutical, nutraceutical and cosmetic agents. Specifically, this invention includes an integrated system for the collection of medicinal plants and creation of informatic databases related to these plants. This invention also relates to an improved standardized extraction and fractionation process, which provides significant advantages over the prior art in the terms of simplicity, efficiency of the separations, the quality of the library, low cost of the process and extraordinary throughput. This invention provides details to the structure dereplication process by utilizing the technology such as HPLC/PDA/MS coupled with high throughput bioassay data and an internal pure compound library. It has been proven to be much more efficient and accurate when compared to the prior art methods. Finally, the Phytologix.TM. platform has been approved as a realistic and efficient process by the demonstration of the whole process of discovery and development of natural COX-2 and tyrosinase inhibitors as novel nutraceutical and cosmetic products.
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