Methods of inhibiting the binding of a CD8+ T cell to a class I MHC employing a modified beta 2 microglobulin
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United States of America Patent
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Issued Date -
Jun 12, 2003
app pub date -
Jun 17, 2002
filing date -
Dec 17, 1999
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Abandoned
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Abstract
The present invention provides a method of inhibiting the binding of a CD8.sup.+ T cell to a class I Major Histocompatibility Complex (MHC). The method comprises exposing the class I MHC to a modified .beta..sub.2-microglobulin whose binding to CD8 is inhibited. Also provided are modified .beta..sub.2-microglobulin molecules and nucleic acids encoding such molecules.
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