ENHANCING THE CIRCULATING HALF LIFE OF ANTIBODY-BASED FUSION PROTEINS
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United States of America Patent
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Issued Date -
Jun 5, 2003
app pub date -
Feb 24, 1999
filing date -
Feb 25, 1998
priority date (Note) -
Abandoned
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Abstract
Disclosed are methods for the genetic construction and expression of antibody-based fusion proteins with enhanced circulating half-lives. The fusion proteins of the present invention lack the ability to bind to immunoglobulin Fc receptors, either as a consequence of the antibody isotype used for fusion protein construction, or through directed mutagenesis of antibody isotypes that normally bind Fc receptors. The fusion proteins of the present invention may also contain a functional domain capable of binding an immunoglobulin protection receptor.
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