Importance

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Abstract

Compounds, compositions containing compounds, methods of sing compounds, and processes of making compounds, of formula I containing at least one ring nitrogen: 1 or a pharmaceutically acceptable base or acid addition salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: X is double-bonded oxygen or --OH; when R.sup.7 is present, it is hydrogen or lower alkyl; Y represents the atoms necessary to form a fused mono-, bi- or tricyclic, carbocyclic or heterocyclic ring, wherein each individual ring has 5-6 ring member atoms; and Z is (i) --CHR.sup.2CHR.sup.3-- wherein R.sup.2 and R.sup.3 are independently hydrogen, alkyl, aryl, or aralkyl; (ii) --R.sup.6C.dbd.CR.sup.3-- wherein R.sup.3 and R.sup.6 are independently hydrogen, lower alkyl, aryl, aralkyl, halo, --NO.sub.2, --COOR.sup.7, or --NR.sup.7R.sup.8 where R.sup.8 is independently hydrogen or C.sub.1-C.sub.9 alkyl, or R.sup.6 and R.sup.3, taken together, form a fused aromatic ring, wherein each individual ring has 5-6 ring members; (iii) --R.sup.2C.dbd.N--; (iv) --CR.sup.2(OH)--NR.sup.7--; or (v) --C(O)--NR.sup.7--.

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First Claim