Methods of providing neuroprotection and/or neurorestoration via the neural activin type IIB receptor
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United States of America Patent
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Issued Date -
Jun 5, 2003
app pub date -
Jun 20, 2002
filing date -
Jun 22, 2001
priority date (Note) -
Abandoned
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Abstract
The neural Type IIB activin receptor (ActRIIB) is strongly expressed in the injured brain, in contrast to the near absence of its expression in the uninjured, non-diseased brain. This invention is directed to the use of ActRIIB activating agents and disinhibiting agents in treating neuronal insult (including stroke). This invention provides agents and methods of using agents that activate or disinhibit ActRIIB, and associated intracellular signaling pathways, as neuroprotective and neurorestorative agents that are specifically targeted to the injured brain and selectively to injured regions of the brain.
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