Myocardial imaging agent and preparation method thereof
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United States of America Patent
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Issued Date -
May 8, 2003
app pub date -
Apr 26, 2002
filing date -
Apr 27, 2001
priority date (Note) -
Abandoned
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Abstract
The invention provides tricarbonyl coordination complexes of having the formula: [M(CO).sub.3(MIBI).sub.x(OH.sub.2).sub.3-x].sup.+, wherein M is a radioactive isotope selected from the group consisting of Mn, .sup.99mTc, .sup.186Re, and .sup.188Re, MIBI is the ether isonitrile 2-methoxy isobutylisonitrile (CN--CH.sub.2--C(CH.sub.3).sub.2--OCH.sub.3)-, and wherein x=1 to 3. The compositions are useful as myocardial imaging agents. The compositions of the invention exhibit fast cardiac uptake, fast lung clearance, and low liver background. The invention also provides methods for preparing the tricarbonyl coordination complexes, method for preparing the coordination complex [M(CO).sub.3(OH.sub.2).sub.-3].sup.+, radiopharmaceutical compositions comprising the tricarbonyl coordination complexes, and methods for imaging body tissues using the tricarbonyl coordination complexes.
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