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Abstract

The invention pertains to compositions and methods to treat the adverse effects of mustard chemicals and other toxic compounds, such as chemical warfare agents, exposure to which normally induces vesicating type response in mammals. In a rodent eye model at fixed concentrations of such a vesicant, compositions comprising (a) a matrix metalloproteinase inhibitor, MMPI, and (b) a protease inhibitor, PI, such as a serine protease inhibitor, SPI, a significant reduction in morbidity is achieved with increased concentrations of the compositions of this invention, as compared with an MMPI inhibitor alone or vehicle alone. Furthermore, compositions comprising the MMPI, the SPI, and in addition, an anti-inflammatory compound, in a vehicle appropriate to the type of tissue damage to be protected against from vesicant exposure, achieves both reduction in total tissue damage and inflammation, as compared with anti-inflammatory composition alone. Chemicals having more than one property, such as MMPI and AIA properties, are also disclosed. Certain combinations disclosed are applied to treat injuries due to acids and bases.

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First Claim