Fenofibrate galenic formulations and method for obtaining same
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United States of America Patent
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Issued Date -
May 1, 2003
app pub date -
Jun 19, 2002
filing date -
Dec 31, 1999
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a pharmaceutical composition for the oral administration of fenofibrate in the form of a preconcentrate capable of forming an oil-in-water microemulsion spontaneously on contact with an aqueous medium, of the type comprising: a lipophilic phase preferably comprising an oil based on glycerol or propylene glycol esters; and an emulsifying system comprising: a lipophilic surfactant; and a hydrophilic co-surfactant. According to the invention, this composition is characterized in that it also comprises vitamin E acetate in a sufficient amount to stabilize said preconcentrate without the incorporation of an additional hydrophilic component, and makes it possible to prepare novel drugs in the form of sealed gelatin capsules or soft capsules.
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