Combinatorial protein domains
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United States of America Patent
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app pub date -
Apr 10, 2002
filing date -
Feb 3, 2000
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Abandoned
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Abstract
The invention relates to a pharmaceutical composition comprising a chimeric, folded protein domain comprising two or more sequence segments from parent amino acid sequences that are not homologous. The invention more particularly relates to compositions comprising a chimeric, folded protein domain comprising two or more sequence segments wherein each of the sequence segments: is not designed or selected to consist solely of a single complete protein structural element and is not designed or selected to consist solely of an entire protein domain; and, in isolation, shows no significant folding at the melting temperature of the chimeric protein. The invention also relates to methods for the selection of such protein domains, and to methods of raising an immune response using such domains, and preferably to chimeric domains that display conformational B cell epitopes of at least one of their parent amino acid sequences.
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