Method and apparatus for inactivation of biological contaminants using photosensitizers
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United States of America Patent
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Issued Date -
Apr 17, 2003
app pub date -
May 30, 2002
filing date -
Jul 21, 1998
priority date (Note) -
Abandoned
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Abstract
Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods for inactivation of microorganisms include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer and a quencher to a fluid and exposing the fluid to photoradiation sufficient to active the endogenous photosensitizer whereby microorganisms are inactivated. The quencher reduces side reactions generated by a photosensitizer and light that can damage desired biological components.
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