Methods of preventing ventilator associated pneumonia by oral administration of antimicrobial IB-367 peptides
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United States of America Patent
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Issued Date -
Apr 17, 2003
app pub date -
Feb 12, 2002
filing date -
Feb 13, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention provides methods of preventing respiratory infections associated with intubation and/or mechanical ventilation, such as ventilator-associated pneumonia, in intubated patients. The method generally involves topical administration of a composition comprising an IB-367 peptide to the oral cavity of an intubated patient. As IB-367 peptides engender very little resistance, a significant advantage of the invention is that the prophylactic therapy may be applied without having to worry about creating resistant strains of pathogens.
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