Apparatus and method for rapid disruption of cells or viruses
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United States of America Patent
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May 25, 2004
Grant Date -
Apr 10, 2003
app pub date -
Oct 4, 2001
filing date -
Oct 4, 2001
priority date (Note) -
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Abstract
An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The chamber is defined by at least one wall having an external surface for contacting a transducer device. The transducer device has a vibrating surface for contacting the wall and for vibrating at an operating frequency and amplitude sufficient to generate pressure waves or pressure pulses in the chamber. The transducer device is coupled to the wall with a preload force sufficient to create a stress within the wall. The natural frequency of the wall, when the wall is stressed by the preload force, is equal to the operating frequency of the transducer device or differs from the operating frequency by less than 50% of the operating frequency.
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