Factor xa inhibitors with aryl-amidines and derivatives, and prodrugs thereof
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United States of America Patent
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Issued Date -
Apr 3, 2003
app pub date -
Jul 24, 2002
filing date -
Jan 29, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a pharmaceutically acceptable salt, a prodrug, a hydrate, a solvate or an isomer thereof, which are inhibitors of coagulation enzyme, factor Xa (FXa). The present invention also relates to a pharmaceutical composition containing the compound, and a method of using the same as an anticoagulant agent for treatment and prevention of thrombosis disorders.
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