Polynucleotide

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20030061627A1
SERIAL NO

10224993

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.

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Patent Owner(s)

Patent OwnerAddress
M L LABORATORIES PLCLONDON W1R 7PD

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Antoniou, Michael Edgeware, GB 13 74
Crombie, Robert Basford, GB 8 66

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