Band 3 antigenic peptides, malaria polypeptides and uses thereof
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United States of America Patent
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Issued Date -
Mar 27, 2003
app pub date -
Mar 1, 2002
filing date -
Mar 2, 2001
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Abstract
The invention provides peptides derived from erythroid Band 3 protein, which selectively bind to merozoite surface protein-1 (MSP-1), and/or one or more of the malaria polypeptides: BBP-1, BBP-2, BBP-3, BBP-4, BBP-5, BBP-6, RhopH3, and ABRA and prevent infection by the parasite of a Band 3-expressing cell, such as an erythrocyte. The invention also provides the isolated polypeptides BBP-1, BBP-2, BBP-3, BBP-4, BBP-5, BBP-6, RhopH3, and/or ABRA as well as peptides derived from MSP-1, which selectively bind to erythroid Band 3 protein and prevent parasite invasion into a Band 3-expressing cell, and prevent Plasmodium infection. Methods of using the malaria and MSP1 polypeptides of the invention for malaria prevention and/or treatment (e.g. in vaccines) are also provided. Antibodies that bind to the Band 3 polypeptides and anti-idiotypic antibodies thereto also are provided. Methods for selecting agents which inhibit Band 3-mediated parasite entry into target cells and methods of treatment which involve the polypeptides, antibodies, and anti-idiotypic antibodies also are provided.
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