Endoglucanase mutants and mutant hydrolytic depolymerizing enzymes and uses thereof
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United States of America Patent
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Issued Date -
Mar 20, 2003
app pub date -
Nov 19, 2001
filing date -
May 19, 1999
priority date (Note) -
Abandoned
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Abstract
The invention provides a method for increasing the specific activity of a glycosyl hydrolase on a substrate, comprising replacing a hydrophobic surface binding amino acid of the hydrolase with a positively charged amino acid; and a method for increasing the specific activity of a glycosyl hydrolase on a substrate, comprising replacing an active site associated glycosyl-stabilizing amino acid of the hydrolase with an amino acid, the replacing amino acid not strongly retarding cellobiose from leaving the active site. The invention further provides mutant glycosyl hydrolases, which include Y245G, Y42R, and W82R.
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