Mitogen-activated protein kinase p38-2 and methods of use therefor

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United States of America Patent

SERIAL NO

10198343

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Abstract

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Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

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Patent Owner(s)

Patent OwnerAddress
SIGNAL PHARMACEUTICALS INC4550 TOWNE CENTRE COURT SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Stein, Bernd San Diego, CA 80 601
Yang, Maria X H San Diego, CA 9 29
Young, David B San Diego, CA 14 228

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