Calcineurin modulators
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United States of America Patent
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Issued Date -
Mar 6, 2003
app pub date -
Jul 12, 2002
filing date -
Jul 13, 2001
priority date (Note) -
Abandoned
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Abstract
This invention relates to compositions which are useful for inhibiting and potentiating the activity of cellular calcineurin. These compositions include linear peptides, cyclic peptides, peptide analogs, peptidomimetics, combinatorial chemicals, and whole proteins. The compositions can be used to treat calcineurin- and adapt78-related pathologies such as cardiac, brain, immune system and developmental abnormalities; to protect human cells and tissues against stress damage based on the cytoprotective activity of adapt78; and to modulate cell growth based on the growth-altering activity of adapt78. Transgenic animals overexpressing the human adapt78 transgene are also disclosed, e.g., for developing therapeutic treatments against adapt78- and calcineurin-related pathologies and abnormalities such as cardiac hypertrophy, memory loss, immune system dysfunction, developmental disabilities.
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