Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays

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United States of America Patent

APP PUB NO 20030044836A1
SERIAL NO

10262251

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Abstract

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Systems and methods for enhanced quantitative analysis of hybridization intensity measurements obtained from oligonucleotide probes and other probes exposed to target samples are provided by virtue of the present invention. One embodiment ameliorates the effects of high frequency noise superimposed on a hybridization intensity measurement signal measured over successive probe alignments to a target sample sequence. Detection of expressed genes and ESTs and quantitative measurement of expression level may be improved. Mutation detection and base calling may be improved.

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Patent Owner(s)

Patent OwnerAddress
PRINCETON UNIVERSITY OFFICE OF TECHNOLOGY & TRADEMARK LICENSINGFIFTH FLOOR NEW SOUTH BUILDING POST OFFICE BOX 36 PRINCETON NJ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alon, Uri Princeton, NJ 12 249
Levine, Arnold J Princeton, NJ 22 422

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