DIagnostic reagents and methods for antibody against hepatitis b surface antigen and for antibody against hepatitis b virus
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United States of America Patent
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Issued Date -
Feb 13, 2003
app pub date -
Jul 25, 2002
filing date -
Feb 1, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates to diagnostic reagents for antibody against hepatitis B surface antigen and for antibody against hepatitis B virus using a sandwich immunoassay as a quantitative or qualitative analysis method for antibody against hepatitis B surface antigen and for antibody against hepatitis B virus, characterized in that each diagnostic reagent comprises a pair of hepatitis B surface antigens which are different each other and composed of primary antigen immobilized on a solid support and secondary antigen conjugated to a marker. Also, the present invention relates to preparation methods thereof. Further, the present invention relates to diagnostic methods for antibody against hepatitis B surface antigen and for antibody against hepatitis B virus. In accordance with the present invention, there are provided diagnostic reagents and methods with markedly enhanced sensitivity and specificity in comparison to diagnostic reagents and methods in which single kind of hepatitis B virus surface antigens are used.
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