Methods for enhancing animal growth and cell proliferation by elimination of the cyclin-dependent kinase inhibitor function of p27Kip1
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United States of America Patent
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Issued Date -
Feb 6, 2003
app pub date -
Jan 4, 2002
filing date -
Apr 10, 1996
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Abandoned
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Abstract
This invention provides a recombinant non-human animal lacking the cyclin-dependent kinase inhibitor function of p27.sup.Kip1 and the method for producing the same. This invention also provides a method for increasing the proliferation of the thymic T-cells by treating the thymic T-cells to eliminate the cyclin-dependent kinase inhibition function of p27.sup.Kip1. This invention also provides a method for increasing the proliferation of hematopoietic cells which comprises treating the hematopoietic cells to eliminate the cyclin-dependent kinase inhibitor function of p27.sup.Kip1, thereby increasing the proliferation of the hematopoietic cells. This invention further provides a method for alleviating symptoms of an AIDS patient comprising steps of: a) collecting the lymphocytes or other cells from an AIDS patient; b) treating the collected cells to eliminate the cyclin-dependent kinase inhibition function of p27.sup.Kip1; and c) re-introducing the treated cells to the AIDS patient.
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