Composition and methods to improve neural outcome
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United States of America Patent
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Issued Date -
Feb 6, 2003
app pub date -
Apr 8, 2002
filing date -
Dec 23, 1993
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Abandoned
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Abstract
A method for protecting white matter, axons, and oligodendrocytes of a mammal, especially a human, against degeneration and death resulting from multiple sclerosis or periventricular leucomalacia by increasing the effective concentration of a GPE-related compound in the central nervous system of the mammal. This increase may be achieved by administration to the mammal of an effective amount of a GPE-related compound, a prodrug thereof, or an implant containing cells that express the GPE-related compound or prodrug. The use of a GPE-related compound, a prodrug thereof, or an implant containing cells that express the GPE-related compound or prodrug in the manufacture of a medicament for protecting white matter, axons, and oligodendrocytes of a mammal, especially a human, against degeneration and death resulting from multiple sclerosis or periventricular leucomalacia; and compositions containing a GPE-related compound, a prodrug thereof, or an implant containing cells that express the GPE-related compound or prodrug for protecting white matter, axons, and oligodendrocytes of a mammal, especially a human, against degeneration and death resulting from multiple sclerosis or periventricular leucomalacia.
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