Protein aggregation assays and uses thereof
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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N/A
Issued Date -
Jan 30, 2003
app pub date -
Jun 20, 2002
filing date -
Jun 20, 2001
priority date (Note) -
Abandoned
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Abstract
This invention features methods for identifying agents that modulate protein aggregation or stabilize protein conformation. Exemplary methods include an in vitro aggregation assay, a native state stabilization assay, a cell-based screening assay, and an animal-based screening assay. These methods can be used to identify agents useful for the treatment of conformational diseases resulting from aggregation of a protein.
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