METHODS OF DETERMINING RESISTANCE TO TREATMENT FOR HEPATITIS C VIRUS
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United States of America Patent
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Issued Date -
Jan 16, 2003
app pub date -
Sep 28, 1999
filing date -
Sep 28, 1998
priority date (Note) -
Abandoned
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Abstract
Methods for identifying hepatitis C virus (HCV)-infected subjects responsive to treatment for HCV infection or unlikely to respond to treatment for HCV infection are described. The level of Th2 cytokines in the subject during treatment serves as an indicator of whether the subject is likely to respond to treatment for HCV, e.g., interferon treatment. An elevated level of at least one Th2 cytokine during treatment indicates that an HCV-infected subject is unlikely to respond to a treatment for HCV. A decreased level of at least one Th2 cytokine indicates that an HCV-infected subject is responsive to a treatment for HCV. In a preferred embodiment, IL-10 levels are detected to identify subjects responsive to or unlikely to respond to interferon treatment.
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