Reversibly inactivated acidified plasmin
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United States of America Patent
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Issued Date -
Jan 16, 2003
app pub date -
May 10, 2002
filing date -
Nov 13, 1999
priority date (Note) -
Abandoned
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Abstract
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.
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