Process for the preparation of epothilone analogs
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United States of America Patent
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app pub date -
Sep 5, 2001
filing date -
Feb 1, 2001
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Abstract
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
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