Molecular conjugates for use in treatment of cancer
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United States of America Patent
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Nov 30, 2004
Grant Date -
Dec 26, 2002
app pub date -
Mar 25, 2002
filing date -
Mar 23, 2001
priority date (Note) -
Expired
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Abstract
A molecular conjugate is provided having the formula: ##STR1## wherein n is the conjugation number, P is a moiety of a carrier molecule such as a protein, R.sub.1 is a moiety of a biologically active molecule or its analogs, derivatives, salts or secondary amines, Z is --O-- or --NH--, and Y is a straight or branched alkyl having 1 to 20 carbons optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl, electron-withdrawing or electron-donating groups. Compounds and methods useful in producing such molecular conjugates are also provided, as well as methods of concentrating biologically active molecules in selected target cells of a patient that comprise administering to the patient a selected dose of such molecular conjugates.
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