Process for the production of a reversibly inactive acidified plasmin composition
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United States of America Patent
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Issued Date -
Dec 19, 2002
app pub date -
May 10, 2002
filing date -
Nov 13, 1999
priority date (Note) -
Abandoned
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Abstract
Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The purified plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluded at a low pH. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.
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