Terminally-branched polymeric linkers and polymeric conjugates containing the same
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United States of America Patent
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Issued Date -
Dec 5, 2002
app pub date -
Feb 19, 2002
filing date -
Feb 20, 2001
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Abandoned
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Abstract
Terminally-branched polymeric prodrug platforms capable of high degrees of loading are disclosed. In preferred aspects of the invention, the prodrug platform releases multiple parent compounds after each branch holding the active agent undergoes a benzyl elimination reaction. Methods of preparing the prodrugs and using the same in the treatment of mammals are also disclosed. In one preferred aspect, polymeric conjugates such as 1 are provided.
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