Methods and compositions for modifying biologically active target molecules
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United States of America Patent
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Issued Date -
Dec 5, 2002
app pub date -
Oct 19, 2001
filing date -
Oct 20, 2000
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides a method of modifying a target substance by contacting the target substance with a catalyst that catalyzes the modification of the target substance. In a preferred embodiment, the method comprises labeling a target substance by contacting the target substance with a label and a catalyst that catalyzes the attachment of the label to the target substance. Preferably, the catalyst catalyzes selectively the reaction between a specific target molecule and a specific label. The attachment of labels may be used to inactivate a biologically active target substance or otherwise modulate its activity. Alternatively, the method may be used to label the target molecule with a detectable label suitable for the sensitive detection of the target substance.
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