ADENOVIRAL TRANSFER VECTOR FOR THE GENE TRANSPORT OF A DNA SEQUENCE
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United States of America Patent
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Issued Date -
Nov 28, 2002
app pub date -
Feb 19, 1999
filing date -
Feb 20, 1998
priority date (Note) -
Abandoned
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Abstract
An adenoviral transfer vector for the gene transport of a DNA sequence, which is produced from an adenoviral plasmid which no longer expresses any natural adenoviral proteins and comprises a) a first DNA sequence with the left inverted terminal repeat (ITR) sequence and a packaging signal of the wild-type adenovirus (serotype 5) and b) a second DNA sequence with the right inverted terminal repeat (ITR) sequence of the wild-type adenovirus (serotype 5) and c) cleavage sites for restriction endonucleases which do not occur in the therapeutic genes and/or marker genes to be incorporated between the adenoviral DNA sequences, and preferably d) the ITRs are enclosed by cleavage sites of a restriction endonuclease which cuts but rarely (i.e. the recognition sequence in .gtoreq.8 base pairs), preferybly Fsel, which makes it possible to cut out the adenoviral portion of the transfer vectors, is described.
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